diff --git a/.flake8 b/.flake8
new file mode 100644
index 0000000000..c4094af462
--- /dev/null
+++ b/.flake8
@@ -0,0 +1,9 @@
+[flake8]
+exclude = build,.git,.tox,./tests/.env
+extend-ignore = E203
+max-line-length = 88
+per-file-ignores =
+    django/core/cache/backends/filebased.py:W601
+    django/core/cache/backends/base.py:W601
+    django/core/cache/backends/redis.py:W601
+    tests/cache/tests.py:W601
diff --git a/MANIFEST.in b/MANIFEST.in
index 3eacc18604..63c1609431 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -13,5 +13,4 @@ graft extras
 graft js_tests
 graft scripts
 graft tests
-global-exclude __pycache__
 global-exclude *.py[co]
diff --git a/docs/internals/contributing/writing-code/coding-style.txt b/docs/internals/contributing/writing-code/coding-style.txt
index 7f825da90a..73c120f71e 100644
--- a/docs/internals/contributing/writing-code/coding-style.txt
+++ b/docs/internals/contributing/writing-code/coding-style.txt
@@ -46,7 +46,7 @@ Python style
 * Unless otherwise specified, follow :pep:`8`.
 
   Use :pypi:`flake8` to check for problems in this area. Note that our
-  ``setup.cfg`` file contains some excluded files (deprecated modules we don't
+  ``.flake8`` file contains some excluded files (deprecated modules we don't
   care about cleaning up and some third-party code that Django vendors) as well
   as some excluded errors that we don't consider as gross violations. Remember
   that :pep:`8` is only a guide, so respect the style of the surrounding code
diff --git a/docs/internals/howto-release-django.txt b/docs/internals/howto-release-django.txt
index 4fb0df4c73..c0a8ab8ab1 100644
--- a/docs/internals/howto-release-django.txt
+++ b/docs/internals/howto-release-django.txt
@@ -83,7 +83,7 @@ permissions.
 
   .. code-block:: shell
 
-      $ python -m pip install wheel twine
+      $ python -m pip install build twine
 
 * Access to `Django's project on PyPI <https://pypi.org/project/Django/>`_ to
   upload binaries, ideally with extra permissions to `yank a release
@@ -345,10 +345,11 @@ issuing **multiple releases**, repeat these steps for each release.
    <2719a7f8c161233f45d34b624a9df9392c86cc1b>`).
 
    #. If this is a pre-release package also update the "Development Status"
-      trove classifier in ``setup.cfg`` to reflect this. An ``rc`` pre-release
-      should not change the trove classifier (:commit:`example commit for alpha
-      release <eeeacc52a967234e920c001b7908c4acdfd7a848>`, :commit:`example
-      commit for beta release <25fec8940b24107e21314ab6616e18ce8dec1c1c>`).
+      trove classifier in ``pyproject.toml`` to reflect this. An ``rc``
+      pre-release should not change the trove classifier (:commit:`example
+      commit for alpha release <eeeacc52a967234e920c001b7908c4acdfd7a848>`,
+      :commit:`example commit for beta release
+      <25fec8940b24107e21314ab6616e18ce8dec1c1c>`).
 
    #. Otherwise, make sure the classifier is set to
       ``Development Status :: 5 - Production/Stable``.
@@ -370,8 +371,8 @@ issuing **multiple releases**, repeat these steps for each release.
 
 #. Make sure you have an absolutely clean tree by running ``git clean -dfx``.
 
-#. Run ``make -f extras/Makefile`` to generate the release packages. This will
-   create the release packages in a ``dist/`` directory.
+#. Run ``python -m build`` to generate the release packages. This will create
+   the release packages in a ``dist/`` directory.
 
 #. Generate the hashes of the release packages:
 
diff --git a/docs/topics/auth/passwords.txt b/docs/topics/auth/passwords.txt
index 4d5f845a57..68f5453d54 100644
--- a/docs/topics/auth/passwords.txt
+++ b/docs/topics/auth/passwords.txt
@@ -97,7 +97,7 @@ To use Argon2id as your default storage algorithm, do the following:
 #. Install the :pypi:`argon2-cffi` package. This can be done by running
    ``python -m pip install django[argon2]``, which is equivalent to
    ``python -m pip install argon2-cffi`` (along with any version requirement
-   from Django's ``setup.cfg``).
+   from Django's ``pyproject.toml``).
 
 #. Modify :setting:`PASSWORD_HASHERS` to list ``Argon2PasswordHasher`` first.
    That is, in your settings file, you'd put::
@@ -128,7 +128,7 @@ To use Bcrypt as your default storage algorithm, do the following:
 #. Install the :pypi:`bcrypt` package. This can be done by running
    ``python -m pip install django[bcrypt]``, which is equivalent to
    ``python -m pip install bcrypt`` (along with any version requirement from
-   Django's ``setup.cfg``).
+   Django's ``pyproject.toml``).
 
 #. Modify :setting:`PASSWORD_HASHERS` to list ``BCryptSHA256PasswordHasher``
    first. That is, in your settings file, you'd put::
diff --git a/extras/Makefile b/extras/Makefile
deleted file mode 100644
index 66efd0d451..0000000000
--- a/extras/Makefile
+++ /dev/null
@@ -1,9 +0,0 @@
-all: sdist bdist_wheel
-
-sdist:
-	python setup.py sdist
-
-bdist_wheel:
-	python setup.py bdist_wheel
-
-.PHONY : sdist bdist_wheel
diff --git a/pyproject.toml b/pyproject.toml
index f8632ac3ce..51c4a31173 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,12 +1,68 @@
 [build-system]
-requires = ['setuptools>=40.8.0']
-build-backend = 'setuptools.build_meta'
+requires = ["setuptools>=61.0.0,<69.3.0"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "Django"
+dynamic = ["version"]
+requires-python = ">= 3.10"
+dependencies = [
+    "asgiref>=3.7.0",
+    "sqlparse>=0.3.1",
+    "tzdata; sys_platform == 'win32'",
+]
+authors = [
+  {name = "Django Software Foundation", email = "foundation@djangoproject.com"},
+]
+description = "A high-level Python web framework that encourages rapid development and clean, pragmatic design."
+readme = "README.rst"
+license = {text = "BSD-3-Clause"}
+classifiers = [
+    "Development Status :: 2 - Pre-Alpha",
+    "Environment :: Web Environment",
+    "Framework :: Django",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: BSD License",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3 :: Only",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3.11",
+    "Programming Language :: Python :: 3.12",
+    "Topic :: Internet :: WWW/HTTP",
+    "Topic :: Internet :: WWW/HTTP :: Dynamic Content",
+    "Topic :: Internet :: WWW/HTTP :: WSGI",
+    "Topic :: Software Development :: Libraries :: Application Frameworks",
+    "Topic :: Software Development :: Libraries :: Python Modules",
+]
+
+[project.optional-dependencies]
+argon2 = ["argon2-cffi>=19.1.0"]
+bcrypt = ["bcrypt"]
+
+[project.scripts]
+django-admin = "django.core.management:execute_from_command_line"
+
+[project.urls]
+Homepage = "https://www.djangoproject.com/"
+Documentation = "https://docs.djangoproject.com/"
+"Release notes" = "https://docs.djangoproject.com/en/stable/releases/"
+Funding = "https://www.djangoproject.com/fundraising/"
+Source = "https://github.com/django/django"
+Tracker = "https://code.djangoproject.com/"
 
 [tool.black]
-target-version = ['py310']
-force-exclude = 'tests/test_runner_apps/tagged/tests_syntax_error.py'
+target-version = ["py310"]
+force-exclude = "tests/test_runner_apps/tagged/tests_syntax_error.py"
 
 [tool.isort]
-profile = 'black'
-default_section = 'THIRDPARTY'
-known_first_party = 'django'
+profile = "black"
+default_section = "THIRDPARTY"
+known_first_party = "django"
+
+[tool.setuptools.dynamic]
+version = {attr = "django.__version__"}
+
+[tool.setuptools.packages.find]
+include = ["django*"]
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 29814e54e6..0000000000
--- a/setup.cfg
+++ /dev/null
@@ -1,61 +0,0 @@
-[metadata]
-name = Django
-version = attr: django.__version__
-url = https://www.djangoproject.com/
-author = Django Software Foundation
-author_email = foundation@djangoproject.com
-description = A high-level Python web framework that encourages rapid development and clean, pragmatic design.
-long_description = file: README.rst
-license = BSD-3-Clause
-classifiers =
-    Development Status :: 2 - Pre-Alpha
-    Environment :: Web Environment
-    Framework :: Django
-    Intended Audience :: Developers
-    License :: OSI Approved :: BSD License
-    Operating System :: OS Independent
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3 :: Only
-    Programming Language :: Python :: 3.10
-    Programming Language :: Python :: 3.11
-    Programming Language :: Python :: 3.12
-    Topic :: Internet :: WWW/HTTP
-    Topic :: Internet :: WWW/HTTP :: Dynamic Content
-    Topic :: Internet :: WWW/HTTP :: WSGI
-    Topic :: Software Development :: Libraries :: Application Frameworks
-    Topic :: Software Development :: Libraries :: Python Modules
-project_urls =
-    Documentation = https://docs.djangoproject.com/
-    Release notes = https://docs.djangoproject.com/en/stable/releases/
-    Funding = https://www.djangoproject.com/fundraising/
-    Source = https://github.com/django/django
-    Tracker = https://code.djangoproject.com/
-
-[options]
-python_requires = >=3.10
-packages = find:
-include_package_data = true
-zip_safe = false
-install_requires =
-    asgiref >= 3.7.0
-    sqlparse >= 0.3.1
-    tzdata; sys_platform == 'win32'
-
-[options.entry_points]
-console_scripts =
-    django-admin = django.core.management:execute_from_command_line
-
-[options.extras_require]
-argon2 = argon2-cffi >= 19.1.0
-bcrypt = bcrypt
-
-[flake8]
-exclude = build,.git,.tox,./tests/.env
-extend-ignore = E203
-max-line-length = 88
-per-file-ignores =
-    django/core/cache/backends/filebased.py:W601
-    django/core/cache/backends/base.py:W601
-    django/core/cache/backends/redis.py:W601
-    tests/cache/tests.py:W601
diff --git a/setup.py b/setup.py
deleted file mode 100644
index ef91130d47..0000000000
--- a/setup.py
+++ /dev/null
@@ -1,55 +0,0 @@
-import os
-import site
-import sys
-from distutils.sysconfig import get_python_lib
-
-from setuptools import setup
-
-# Allow editable install into user site directory.
-# See https://github.com/pypa/pip/issues/7953.
-site.ENABLE_USER_SITE = "--user" in sys.argv[1:]
-
-# Warn if we are installing over top of an existing installation. This can
-# cause issues where files that were deleted from a more recent Django are
-# still present in site-packages. See #18115.
-overlay_warning = False
-if "install" in sys.argv:
-    lib_paths = [get_python_lib()]
-    if lib_paths[0].startswith("/usr/lib/"):
-        # We have to try also with an explicit prefix of /usr/local in order to
-        # catch Debian's custom user site-packages directory.
-        lib_paths.append(get_python_lib(prefix="/usr/local"))
-    for lib_path in lib_paths:
-        existing_path = os.path.abspath(os.path.join(lib_path, "django"))
-        if os.path.exists(existing_path):
-            # We note the need for the warning here, but present it after the
-            # command is run, so it's more likely to be seen.
-            overlay_warning = True
-            break
-
-
-setup()
-
-
-if overlay_warning:
-    sys.stderr.write(
-        """
-
-========
-WARNING!
-========
-
-You have just installed Django over top of an existing
-installation, without removing it first. Because of this,
-your install may now include extraneous files from a
-previous version that have since been removed from
-Django. This is known to cause a variety of problems. You
-should manually remove the
-
-%(existing_path)s
-
-directory and re-install Django.
-
-"""
-        % {"existing_path": existing_path}
-    )